Cytokine-Induction of Tumor Necrosis Factor Receptor 2 (TNFR2) is Mediated by STAT3 in Colon Cancer Cells
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چکیده
STAT3 in Colon Cancer Cells Kathryn E. Hamilton, James G. Simmons, Shengli Ding, Laurianne Van Landeghem, P. Kay Lund Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7545 Address correspondence to: P. Kay Lund, 111 Mason Farm Road CB#7545, Chapel Hill, NC 27599-7545. Fax: 919-966-6927; E-mail: [email protected] Running Title: STAT3 dependent TNFR2 induction in colon cancer cell lines
منابع مشابه
Signaling and Regulation Cytokine Induction of Tumor Necrosis Factor Receptor 2 Is Mediated by STAT3 in Colon Cancer Cells
The IL-6/STAT3 and TNFa/NFkB pathways are emerging as critical mediators of inflammation-associated colon cancer. TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/ dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer, and by combined interleukin (IL) 6 and TNFa. Themolecular mechanisms that regulate TNFR2 remain undefined. This study ...
متن کاملCytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
The IL-6/STAT3 and TNFα/NFκB pathways are emerging as critical mediators of inflammation-associated colon cancer. TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer, and by combined interleukin (IL) 6 and TNFα. The molecular mechanisms that regulate TNFR2 remain undefined. This study ...
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تاریخ انتشار 2011